4/21/2021 0 Comments Bcs Class 2 Drug
Furthermore, showcasing the flexibility of KinetiSol, compositions can also be tuned down to match the pharmacokinetic profile of Sporanox, a drug which years after coming off-patent still only has two generics on market.
![]() Itraconazole exhibits very poor oral bioavailability owing to its insolubility in intestinal fluids. Itraconazole: Physicochemical Properties Indication Anti-fungal Melting Point 170C Solubility 0.1 N HCl 4 6 gmL Solubility Water 1 4 ngmL LogP 5.66 pKa 3.7 BCS Class II Result Single-Phase Amorphous Dispersions of Itraconazole and HPMC by KinetiSol In a study conducted by DiNunzio et al., thermal processing of ITZ and HPMC by both hot-melt extrusion (HME) and KinetiSol was investigated. These researchers found that ITZ:HPMC E5 (1:2) amorphous solid dispersions produced by HME were two-phase systems; whereas, the same composition processed by KinetiSol yielded a single-phase amorphous dispersion. These findings are presented in the figure below which shows a single glass transition temperature at 86.02C for the KinetiSol product and two distinct T g s for the melt extruded product. The more homogenous, single-phase KinetiSol system was also determined to produce more rapid and extensive supersaturation of ITZ in simulated gastric fluid versus the HME system (shown above, right). ![]() CASE STUDIES Read about exciting new breakthroughs KinetiSol has been the subject of numerous research articles published in top peer-reviewed journals in recent years. These papers demonstrate unique capabilities of the KinetiSol process and its benefits for amorphous solid dispersion processing. Key advantages of the KinetiSol process are illustrated in these case studies. VIEW ALL CASE STUDIES DisperSol Technologies adapts and applies its disruptive KinetiSol technology to create enhanced, soluble, and highly efficacious pharmaceutical products. Contact Us Ph: 512.686.4740 111 W. Cooperative Way Georgetown, TX 78626 Fax: 512.686.4651.
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